Anaplastic large cell lymphoma, ALK-positive

Definition

A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm characterised by the presence of a translocation involving the ALK gene and expression of ALK fusion protein. Most patients present with peripheral and/or abdominal lymphadenopathy, and often have advanced disease and extranodal involvement.

Inclusions

• Anaplastic large cell lymphoma, CD30-positive

Index Terms