3A20.1
Autoimmune haemolytic anaemia, cold type
Anemia hemolítica autoimune, tipo fria
CategoryDefinition
Cold autoimmune haemolytic anaemia comprises two types of autoimmune haemolytic anaemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold haemoglobinuria (PCH). CAD is more common in people over the age of 55 years, while PCH typically presents in young children. CAD is caused by IgM autoantibodies while PCH is caused by an IgG immunoglobulin.
Exclusions
- Immune thrombocytopenic purpura
- Haemolytic disease of fetus or newborn
Inclusions
- Cold haemagglutinin disease
Index Terms
Autoimmune haemolytic anaemia, cold typeautoimmune haemolytic anaemia due to cold antibodiesidiopathic cold autoimmune haemolytic anaemiaautoimmune cold senseautoimmune cold sensitivitycold autoimmune haemolytic anaemiacold antibody haemolytic anaemiacold haemolytic diseasecryopathic haemolytic anaemiasecondary cold type haemolytic anaemiasymptomatic cold type haemolytic anaemiaCold haemagglutinin diseaseCold agglutinin diseaseCHAD - [cold hemagglutinin disease]cold agglutinin disease or haemoglobinuriaCold agglutinin haemoglobinuriacold hemagglutinin disease