4A44.A1

Granulomatosis with polyangiitis

Granulomatose com poliangiíte

Category

Definition

Necrotizing granulomatous inflammation usually involving the upper and lower respiratory tract, and necrotizing vasculitis affecting predominantly small to medium-sized vessels (e.g., capillaries, venules, arterioles, arteries and veins). Necrotizing glomerulonephritis is common. (Arthritis Rheum 1990;33:1101-1107)

Diagnostic Criteria

At least three out of six of the following criteria:

1. histopathology (granulomatous inflammation within the wall of an artery or in the peri-/extra-vascular area)

2. upper airway involvement

3. laryngo-tracheo-bronchial stenoses

4. pulmonary involvement

5. ANCA positivity

6. renal involvement

Inclusions

  • Wegener granulomatosis

Index Terms

Granulomatosis with polyangiitisWegener granulomatosisNecrotising respiratory granulomatosis