5A00.03
Transient congenital hypothyroidism
Hipotireoidismo congênito transitório
CategoryDefinition
Transient congenital hypothyroidism is defined as transient thyroid dysfunction with mildly elevated thyroid-stimulating hormone (TSH) and low thyroxine (FT4) levels which return to normal either very promptly and spontaneously, or after several months of thyroxine therapy. The disorder is due to a variety of causes including iodine deficiency or exposure to iodine-containing compounds, transplacental passage of blocking maternal antibodies, and dyshormonogenesis.
Exclusions
- Transitory congenital goitre with normal function
Index Terms
Transient congenital hypothyroidismTransient congenital hypothyroidism due to monoallelic or biallelic mutations of dual oxidase 2 mutationTransient congenital hypothyroidism due to heterozygous mutations of monoallelic or biallelic mutations of DUOX2 mutationTransient congenital hypothyroidism due to maternal intake of antithyroid drugsTransient congenital hypothyroidism due to maternal iodine deficiency or excessFetal iodine syndromeTransient congenital hypothyroidism due to neonatal iodine deficiency or excessTransient congenital hypothyroidism due to neonatal iodine exposureTransient congenital hypothyroidism due to transplacental passage of maternal TSH receptor blocking antibodiesTransient congenital hypothyroidism due to heterozygous mutations of THOX2