5A70.0
Pituitary-dependent Cushing disease
Síndrome de Cushing dependente da hipófise
CategoryDefinition
Pituitary-dependent Cushing disease is caused by a pituitary tumour, generally benign (adenoma) but rarely malignant (carcinoma), which secretes adrenocorticotropin (ACTH) autonomously, leading to hypercortisolism. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for this disease but requires considerable neurosurgical expertise and experience in order to optimize patient outcomes.
Index Terms
Pituitary-dependent Cushing diseaseOverproduction of pituitary ACTHPituitary-dependent hyperadrenocorticismCorticotroph pituitary adenomaACTH- [adrenocorticotropic hormone] secreting pituitary adenomaCushing syndrome or disease, pituitary-dependentCushings basophilismCushing's syndrome 3Itsenko-Cushing syndromeItsenko diseasepituitary basophilismpituitary-dependent hypercorticalismsuprarenogenic syndromepituitary ACTH hypersecretionCushing diseaseCushing's disease