Stimulant-induced mood disorder including amphetamines, methamphetamine or methcathinone

Essential (Required) Features:

• The presentation is characterized by mood symptoms (e.g., depressed or elevated mood, decreased engagement in pleasurable activities, increased or decreased energy levels) that develop during or soon after intoxication with or withdrawal from stimulants.
• The intensity or duration of the mood symptoms is substantially in excess of mood symptoms that are characteristic of Stimulant Intoxication or Stimulant Withdrawal.
• The symptoms are not better accounted for by another mental disorder such as a Depressive Disorder, a Bipolar Disorder, or Schizophrenia or Other Primary Psychotic Disorder. Evidence supporting a diagnosis of another mental disorder would include mood symptoms preceding the onset of stimulant use, the symptoms persisting for a substantial period of time after cessation of stimulant use or withdrawal (e.g., 1 month or more), or other evidence of a pre-existing mental disorder with mood symptoms (e.g., a history of prior episodes not associated with stimulant use).
• The symptoms are not a manifestation of another medical condition.
• The symptoms cause significant distress or significant impairment in personal, family, social, educational, occupational or other important areas of functioning.

When making a diagnosis of Stimulant-Induced Mood Disorder, an additional diagnosis indicating the related pattern of stimulant use should also be assigned. These include Episode of Harmful Use of Stimulants, Harmful Pattern of Use of Stimulants, and Stimulant Dependence. A diagnosis of Stimulant Intoxication or Stimulant Withdrawal may also be assigned if applicable.

Specifiers for stimulant-induced mood symptoms:

An additional specifier can be added to denote the presence of either depressive symptoms in the absence of manic symptoms, manic symptoms in the absence of depressive symptoms, or mixed manic and depressive symptoms.

6C46.700 Stimulant-Induced Mood Disorder, including Amphetamines, Methamphetamine or Methcathinone, with depressive symptoms

• All diagnostic requirements for Stimulant-Induced Mood Disorder are met.
• The presentation is characterized by depressive symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.
• Manic symptoms are not present.

6C46.701 Stimulant-Induced Mood Disorder, including Amphetamines, Methamphetamine or Methcathinone, with manic symptoms

• All diagnostic requirements for Stimulant-Induced Mood Disorder are met.
• The presentation is characterized by manic symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.
• Depressive symptoms are not present.

6C46.702 Stimulant-Induced Mood Disorder, including Amphetamines, Methamphetamine or Methcathinone, with mixed depressive and manic symptoms

• All diagnostic requirements for Stimulant-Induced Mood Disorder are met.
• The presentation is characterized by both depressive and manic symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.

6C46.70Z Stimulant-Induced Mood Disorder, including Amphetamines, Methamphetamine or Methcathinone, unspecified

Additional Clinical Features:

• Stimulant-Induced Mood Disorder may present with patterns of symptoms, depending on the specific substance used, that vary according to the characteristics of the user (e.g., genetics, metabolism, personality factors). Stimulants use in higher amounts or over longer periods of time is more likely to be associated with the development of a Stimulant-Induced Mood Disorder.
• Symptoms of Stimulant-Induced Mood Disorder usually resolve or improve after sustained cessation of stimulant use.
• The duration of Substance Withdrawal for some substances can be protracted. For substances with more protracted withdrawal periods, the onset of symptoms of Substance-Induced Mood Disorder can occur up to several weeks after the cessation of substance use. Substance-Induced Mood Disorder symptoms related to substances with more protracted withdrawal periods may also last for correspondingly longer periods of time.
• In cases in which multiple psychoactive substance are used, it is often challenging to distinguish which substance is the cause of the Substance-Induced Mood Disorder. When the specific etiological substance cannot be determined, a diagnosis of Substance-Induced Mood Disorder Due to Multiple Specified Psychoactive Substances including Medications may assigned. In cases of multiple psychoactive substance use in which more than one specific substance can be identified as a cause of the Substance-Induced Mood Disorder, the corresponding specific Substance-Induced Mood Disorder diagnoses should be given instead.

Boundary with Normality (Threshold):

• Symptoms of Stimulant-Induced Mood Disorders should be differentiated from known side effects of psychoactive medication that are not significantly impairing or distressing and from transient physiological aftereffects of intoxication (‘hangover effect’). The duration or severity of the symptoms in Stimulant-Induced Mood Disorders must be in excess of side effects (e.g., transient jitteriness as a side effect of methylphenidate) or ‘hangover effects’ of Stimulants and result in significant distress or impairment of functioning.

Boundaries with Other Disorders and Conditions (Differential Diagnosis):

• Boundary with Stimulant Intoxication and Stimulant Withdrawal, including Amphetamines, Methamphetamine or Methcathinone: Mental or behavioural symptoms that occur during Stimulant Intoxication or Stimulant Withdrawal should only be used as a basis for diagnosing a Stimulant-Induced Mood Disorder if the intensity or duration of the symptoms is substantially in excess of those that are characteristic of Stimulant Intoxication or Stimulant Withdrawal and the symptoms are sufficiently severe to warrant specific clinical attention.
• Boundary with Episode of Harmful Use of Stimulants, Harmful Pattern of Use of Stimulants, or Stimulant Dependence, including Amphetamines, Methamphetamine or Methcathinone: The impact of repeated or continuous use of stimulants characteristic of Harmful Pattern of Use of Stimulants and Stimulants Dependence may include Stimulant-Induced Mood Disorder. Stimulant-Induced Mood Disorders can also be associated with a single episode of stimulant use. In such cases, a Stimulant-Induced Mood Disorder should be diagnosed together with a primary diagnosis of Episode of Harmful Use of Stimulants, Harmful Pattern of Use of Stimulants, or Stimulant Dependence.
• Boundary with mental disorders not induced by stimulants: Stimulant-Induced Mood Disorders are differentiated from mental disorders with similar features that are not induced by stimulants on the basis of their onset, course and clinical features. A diagnosis of Stimulant-Induced Mood Disorder requires evidence from history, physical or mental examination, or laboratory findings of recent stimulant use, intoxication or withdrawal. Most Stimulant-Induced Mental Disorders resolve or improve within several weeks of cessation of stimulant use. Mental disorders not induced by stimulants may precede the onset of stimulant use or may continue to be symptomatic during periods of sustained abstinence. The co-occurrence of stimulant use or withdrawal and onset of symptoms of mental disorders should not be taken as evidence for a presumptive diagnosis of a Stimulant-Induced Mood Disorder. Some people use substances to suppress symptoms of mental disorders (e.g., Schizophrenia and Other Primary Psychotic Disorders, Mood Disorders, Anxiety and Fear-Related Disorders, Personality Disorders) and full symptomatic presentations only emerge upon cessation or reduction in substance use. Furthermore, stimulant use can exacerbate symptoms or precipitate an episode of a pre-existing mental disorder. Finally, stimulant use may be associated with but not aetiologic for new onset of symptoms of a mental disorder. Although a diagnosis of a Stimulant-Induced Mood Disorder should not be assigned under these circumstances, an additional diagnosis of Episode of Harmful Use of Stimulants, Harmful Pattern of Use of Stimulants, or Stimulant Dependence may still be appropriate.