Harmful pattern of use of synthetic cathinones

Essential (Required) Features:

• A pattern of continuous, recurrent, or sporadic use of synthetic cathinones that has caused clinically significant damage to a person’s physical health or mental health (e.g., Synthetic Cathinones-Induced Mood Disorder), or has resulted in behaviour leading to harm to the health of others.
• Harm to health of the individual occurs due to one or more of the following: (1) behaviour related to intoxication; (2) direct or secondary toxic effects on body organs and systems; or (3) a harmful route of administration.
• Harm to health of others includes any form of physical harm, including trauma, or mental disorder that is directly attributable to behaviour related to substance intoxication on the part of the person to whom the diagnosis of Harmful Pattern of Use of Synthetic Cathinones applies.
• The pattern of synthetic cathinone use is evident over a period of at least 12 months if synthetic cathinone use is episodic or at least 1 month if use is continuous.
• Harm to health is not better accounted for by another medical condition or another mental disorder, including another Disorder Due to Substance Use (e.g., Substance Withdrawal).

Note: Harm to the health of the person to whom the diagnosis applies includes injuries caused by behaviour related to intoxication (e.g., impulsive aggressive behaviour, psychomotor impairment leading to injury; acute health problems resulting from substance use (e.g., overdose, acute gastritis, the effects of hypoxia or prolonged hyperactivity or inactivity), and exacerbation or decompensation of pre-existing chronic health problems (e.g., hypertension, liver disease, or peptic ulceration). Harm may also result from a harmful route of administration (e.g., injecting drug use causing blood-borne virus infections, cocaine use causing a perforated nasal septum). The relevant diagnostic codes from other chapters of the ICD-11, including the chapter on Injury, Poisoning or Certain Other Consequences of External Causes, should be used to describe the specific health consequences of the harmful substance use.

Harm to the health of others includes any form of physical harm, including trauma (e.g., impaired driving causing a motor vehicle accident, assaultive behaviour leading to bodily harm to another person) or mental disorder (e.g., Post-Traumatic Stress Disorder arising from an assault by the intoxicated individual) that is directly attributable to behaviour due to substance intoxication on the part of the person to whom the diagnosis of Harmful Pattern of Psychoactive Substance Use applies.

Course Specifiers:

A specifier is used to further describe the harmful pattern of substance use, using a fifth-digit code. The fourth-digit code indicates the substance class (i.e., 7 for synthetic cathinones).

6C47.10 Harmful Pattern of Use of Synthetic Cathinones, episodic

This category is assigned when all the diagnostic requirements for Harmful Pattern of Use of Synthetic Cathinones are met and there is evidence of a pattern of recurrent episodic or intermittent use of synthetic cathinones over a period of at least 12 months that has caused clinically significant harm to a person’s physical or mental health or has resulted in behaviour leading to harm to the health of others.

6C47.11 Harmful Pattern of Use of Synthetic Cathinones, continuous

This category is assigned when all the diagnostic requirements for Harmful Pattern of Use of Synthetic Cathinones are met and there is evidence of a pattern of continuous synthetic cathinone use (daily or almost daily) over a period of at least 1 month that has caused clinically significant harm to a person’s physical or mental health or has resulted in behaviour leading to harm to the health of others.

6C47.1Z Harmful Pattern of Use of Synthetic Cathinones, unspecified

Additional Clinical Features:

• There must be explicit evidence of harm to the individual’s physical or mental health, or of related behaviour due to Synthetic Cathinone Intoxication that has led to harm to the physical or mental health of others. There must also be a clear causal relationship between the harm to health and the episodic or continuous use of synthetic cathinones.
• The likelihood of harm to self or others due behaviour related to intoxication varies substantially by substance. For example, such behaviour is unlikely to arise from caffeine or nicotine intoxication.
• As more information becomes available about symptoms and behaviours related to the pattern of synthetic cathinone use as well as physiological features indicative of neuroadaptation to the substance, the diagnosis may be changed to Synthetic Cathinone Dependence if diagnostic requirements are met.

Boundary with Normality (Threshold):

• The diagnosis of Harmful Pattern of Use of Synthetic Cathinones requires clinically significant harm to the individual’s physical or mental health or that of others. Examples of impact on physical or mental health that would not be considered clinically significant include mild hangovers, brief episodes of vomiting, or transient depressed mood.
• A pattern of synthetic cathinone use may cause a range of problems in functioning (e.g., missed appointments, arguments with loved ones) that are not sufficiently severe to constitute clinically significant harm to physical or mental health. Such problems are not a sufficient basis for a diagnosis of Harmful Pattern of Use of Synthetic Cathinones.

Developmental Presentations:

• Harmful Pattern of Use of Synthetic Cathinones is often a characteristic of late adolescence and young adulthood, and injuries and the consequences of aggressive behaviour are particularly common in this age group.
• Harmful Pattern of Use of Synthetic Cathinones in older adults may cause injuries and fractures due to the combination of lowered tolerance, psychomotor impairment induced by a substance, and disorders associated with ageing such as osteoporosis and Dementia.

Sex- and/or Gender-Related Features:

• The prevalence of Harmful Pattern of Use of Synthetic Cathinones is higher in males than females, but the gender differential is smaller in countries where women play a greater role in the workforce. Gender differences in injuries and other forms of harm due to substance use are recognized.

Boundaries with Other Disorders and Conditions (Differential Diagnosis):

• Boundary with Hazardous Use of Synthetic Cathinones: Hazardous Use of Synthetic Cathinones is classified in the chapter on ‘Factors Influencing Health Status or Contact with Health Services’ in the ICD-11 and not in the chapter on Mental, Behavioural, and Neurodevelopmental Disorders. Hazardous Use of Synthetic Cathinones appreciably increases the risk of harmful physical or mental health consequences to the user or to others to an extent that warrants attention and advice from health professionals, but has not resulted in specific identifiable harm and therefore does not meet the diagnostic requirements for Harmful Pattern of Use of Synthetic Cathinones.
• Boundary with Episode of Harmful Use of Synthetic Cathinones: If the harm to health is a result of a single episode of use rather than a pattern of substance use, whether episodic or continuous, a diagnosis of Episode of Harmful Use of Synthetic Cathinones should be assigned. Synthetic Cathinone use is generally considered to be following a pattern if there has been at least episodic or intermittent use over a period of at least 12 months. If harm is caused by use of synthetic cathinones but no information is available about the pattern or history of synthetic cathinone use, a diagnosis of Episode of Harmful Use of Synthetic Cathinones may be assigned until such time as evidence for a pattern of use is ascertained.
• Boundary with Synthetic Cathinone Dependence: In Synthetic Cathinone Dependence, individuals use synthetic cathinones persistently despite harm and adverse consequences. Harm caused by such use may be similar to that observed in Harmful Pattern of Use of Synthetic Cathinones. However, Synthetic Cathinone Dependence also includes additional features of impaired ability to control use and increasing priority given to the substance use over other activities. Physiological features (e.g., tolerance) may also be present. If all diagnostic requirements for Synthetic Cathinone Dependence are met, Harmful Pattern of Use of Synthetic Cathinones should not be assigned.
• Boundary with Synthetic Cathinone Intoxication: Synthetic Cathinone Intoxication is defined by synthetic cathinone use that results in clinically significantly, transient synthetic cathinone-specific symptoms. Recovery from Synthetic Cathinone Intoxication is generally complete and absent of physical or mental sequelae. A pattern or repeated intoxication may or may not result in harm to a person’s physical or mental health or to the health of others. If there is continuing damage or harm as a result of repeated or continuous use of synthetic cathinones, a diagnosis of Harmful Pattern of Use of Synthetic Cathinones may be assigned. If relevant at the time of the clinical encounter (e.g., in an emergency room), Harmful Pattern of Use of Synthetic Cathinones may be diagnosed with an associated diagnosis of Synthetic Cathinone Intoxication.
• Boundary with Synthetic Cathinone Withdrawal: Synthetic Cathinone Withdrawal occurs upon cessation or reduction of a substance in the context of physiological dependence or when synthetic cathinones have been taken for a prolonged period or in large amounts. Some features of synthetic cathinone withdrawal may include physical or mental harm (e.g., depressed or dysphoric mood, insomnia or (more commonly) hypersomnia, vivid and unpleasant dreams, increased appetite). If the symptoms are entirely explained by the Synthetic Cathinone Withdrawal, an additional diagnosis of Harmful Pattern of Use of Synthetic Cathinones is not warranted. However, if the symptoms substantially exceed the expected withdrawal syndrome in duration or type or severity and the diagnostic requirements for Synthetic Cathinone Dependence are not met, Harmful Pattern of Use of Synthetic Cathinones can be assigned as the primary diagnosis, with an associated diagnosis of Synthetic Cathinone Withdrawal.
• Boundary with Synthetic Cathinone-Induced Mental Disorders: If a Synthetic Cathinone-Induced Mental Disorder has occurred as a form of harm resulting from a pattern of synthetic cathinone use, both Harmful Pattern of Use of Synthetic Cathinones and the relevant Synthetic Cathinone-Induced Mental Disorder should be diagnosed (e.g., Harmful Pattern of Synthetic Cathinone Use with Synthetic Cathinone-Induced Anxiety Disorder).
• Boundary with other mental disorders and other medical conditions: Numerous mental disorders as well as subthreshold symptoms may co-occur with episodic or continuous patterns of synthetic cathinone use. Similarly, continuous or episodic synthetic cathinone use increases the risk for mental disorders as well as other medical conditions. Co-occurring mental disorders and comorbid medical conditions should be diagnosed separately, along with a diagnosis of Harmful Pattern of Use of Synthetic Cathinones.