Mood disorder induced by multiple specified psychoactive substances

Essential (Required) Features:

• The presentation is characterized by mood symptoms (e.g., depressed or elevated mood, decreased engagement in pleasurable activities, increased or decreased energy levels) that develop during or soon after intoxication with or withdrawal from multiple specified psychoactive substances.
• The intensity or duration of the mood symptoms is substantially in excess of mood symptoms that are characteristic of Intoxication due to Multiple Specified Psychoactive Substances or Multiple Specified Psychoactive Substance Withdrawal.
• The symptoms are not better accounted for by another mental disorder such as a Depressive Disorder, a Bipolar Disorder, or Schizophrenia or Other Primary Psychotic Disorder. Evidence supporting a diagnosis of another mental disorder would include mood symptoms preceding the onset of multiple specified psychoactive substance use, the symptoms persisting for a substantial period of time after cessation of multiple specified psychoactive substance use or withdrawal (e.g., 1 month or more), or other evidence of a pre-existing mental disorder with mood symptoms (e.g., a history of prior episodes not associated with multiple specified psychoactive substance use).
• The symptoms are not a manifestation of another medical condition.
• The symptoms cause significant distress or significant impairment in personal, family, social, educational, occupational or other important areas of functioning.

When making a diagnosis of Mood Disorder induced by Multiple Specified Psychoactive Substances, an additional diagnosis indicating the related pattern of multiple specified psychoactive substance use should also be assigned. These include Episode of Harmful Use of Multiple Specified Psychoactive Substances, Harmful Pattern of Use of Multiple Specified Psychoactive Substances, and Multiple Specified Psychoactive Substance Dependence. A diagnosis of Intoxication due to Multiple Specified Psychoactive Substances or Multiple Specified Psychoactive Substance Withdrawal may also be assigned if applicable.

Specifiers for multiple specified psychoactive substance-induced mood symptoms:

An additional specifier can be added to denote the presence of either depressive symptoms in the absence of manic symptoms, manic symptoms in the absence of depressive symptoms, or mixed manic and depressive symptoms.

6C4F.700 Mood Disorder induced by Multiple Specified Psychoactive Substances with depressive symptoms

• All diagnostic requirements for Mood Disorder induced by Multiple Specified Psychoactive Substances are met.
• The presentation is characterized by depressive symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.
• Manic symptoms are not present.

6C4F.701 Mood Disorder induced by Multiple Specified Psychoactive Substances with manic symptoms

• All diagnostic requirements for Multiple Specified Psychoactive Substance -Induced Mood Disorder are met.
• The presentation is characterized by manic symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.
• Depressive symptoms are not present.

6C4F.702 Mood Disorder induced by Multiple Specified Psychoactive Substances with mixed depressive and manic symptoms

• All diagnostic requirements for Multiple Specified Psychoactive Substance -Induced Mood Disorder are met.
• The presentation is characterized by both depressive and manic symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.

6C4F.70Z Mood Disorder induced by Multiple Specified Psychoactive Substances, unspecified

Additional Clinical Features:

• Mood Disorder induced by Multiple Specified Psychoactive Substances may present with patterns of symptoms, depending on the specific substance used, that vary according to the characteristics of the user (e.g., genetics, metabolism, personality factors). Multiple Specified Psychoactive Substances use in higher amounts or over longer periods of time is more likely to be associated with the development of a Mood Disorder induced by Multiple Specified Psychoactive Substances.
• Symptoms of Mood Disorder induced by Multiple Specified Psychoactive Substances usually resolve or improve after sustained cessation of multiple specified psychoactive substance use.
• The duration of Substance Withdrawal for some substances can be protracted. For substances with more protracted withdrawal periods, the onset of symptoms of Substance-Induced Mood Disorder can occur up to several weeks after the cessation of substance use. Substance-Induced Mood Disorder symptoms related to substances with more protracted withdrawal periods may also last for correspondingly longer periods of time.
• In cases in which multiple psychoactive substance are used, it is often challenging to distinguish which substance is the cause of the Substance-Induced Mood Disorder. When the specific etiological substance cannot be determined, a diagnosis of Substance-Induced Mood Disorder Due to Multiple Specified Psychoactive Substances including Medications may assigned. In cases of multiple psychoactive substance use in which more than one specific substance can be identified as a cause of the Substance-Induced Mood Disorder, the corresponding specific Substance-Induced Mood Disorder diagnoses should be given instead.

Boundary with Normality (Threshold):

• Symptoms of Mood Disorder induced by Multiple Specified Psychoactive Substances should be differentiated from known side effects of psychoactive medication that are not significantly impairing or distressing and from transient physiological aftereffects of intoxication (‘hangover effect’). The duration or severity of the symptoms in Mood Disorder induced by Multiple Specified Psychoactive Substances must be in excess of side effects (e.g., transient jitteriness as a side effect of methylphenidate) or ‘hangover effects’ (e.g., transient low mood following alcohol use) of Multiple Specified Psychoactive Substances and result in significant distress or impairment of functioning.

Boundaries with Other Disorders and Conditions (Differential Diagnosis):

• Boundary with Intoxication due to Multiple Specified Psychoactive Substances and Multiple Specified Psychoactive Substance Withdrawal: Mental or behavioural symptoms that occur during Intoxication due to Multiple Specified Psychoactive Substances or Multiple Specified Psychoactive Substance Withdrawal should only be used as a basis for diagnosing a Mood Disorder induced by Multiple Specified Psychoactive Substances if the intensity or duration of the symptoms is substantially in excess of those that are characteristic of Intoxication due to Multiple Specified Psychoactive Substances or Multiple Specified Psychoactive Substance Withdrawal and the symptoms are sufficiently severe to warrant specific clinical attention.
• Boundary with Episode of Harmful Use of Multiple Specified Psychoactive Substances, Harmful Pattern of Use of Multiple Specified Psychoactive Substances, or Multiple Specified Psychoactive Substance Dependence: The impact of repeated or continuous use of multiple specified psychoactive substances characteristic of Harmful Pattern of Use of Multiple Specified Psychoactive Substances and Multiple Specified Psychoactive Substances Dependence may include Mood Disorder induced by Multiple Specified Psychoactive Substances. Mood Disorder induced by Multiple Specified Psychoactive Substances can also be associated with a single episode of multiple specified psychoactive substance use. In such cases, a Mood Disorder induced by Multiple Specified Psychoactive Substances should be diagnosed together with a primary diagnosis of Episode of Harmful Use of Multiple Specified Psychoactive Substances, Harmful Pattern of Use of Multiple Specified Psychoactive Substances, or Multiple Specified Psychoactive Substance Dependence.
• Boundary with mental disorders not induced by multiple specified psychoactive substances: Mood Disorder induced by Multiple Specified Psychoactive Substances are differentiated from mental disorders with similar features that are not induced by multiple specified psychoactive substances on the basis of their onset, course and clinical features. A diagnosis of Mood Disorder induced by Multiple Specified Psychoactive Substances requires evidence from history, physical or mental examination, or laboratory findings of recent multiple specified psychoactive substance use, intoxication or withdrawal. Most Multiple Specified Psychoactive Substance-Induced Mental Disorders resolve or improve within several weeks of cessation of multiple specified psychoactive substance use. Mental disorders not induced by multiple specified psychoactive substances may precede the onset of multiple specified psychoactive substance use or may continue to be symptomatic during periods of sustained abstinence. The co-occurrence of multiple specified psychoactive substance use or withdrawal and onset of symptoms of mental disorders should not be taken as evidence for a presumptive diagnosis of a Mood Disorder induced by Multiple Specified Psychoactive Substances. Some people use substances to suppress symptoms of mental disorders (e.g., Schizophrenia and Other Primary Psychotic Disorders, Mood Disorders, Anxiety and Fear-Related Disorders, Personality Disorders) and full symptomatic presentations only emerge upon cessation or reduction in substance use. Furthermore, multiple specified psychoactive substance use can exacerbate symptoms or precipitate an episode of a pre-existing mental disorder. Finally, multiple specified psychoactive substance use may be associated with but not aetiologic for new onset of symptoms of a mental disorder. Although a diagnosis of a Mood Disorder induced by Multiple Specified Psychoactive Substances should not be assigned under these circumstances, an additional diagnosis of Episode of Harmful Use of Multiple Specified Psychoactive Substances, Harmful Pattern of Use of Multiple Specified Psychoactive Substances, or Multiple Specified Psychoactive Substance Dependence may still be appropriate.