Mood disorder induced by unknown or unspecified psychoactive substance

Essential (Required) Features:

• The presentation is characterized by mood symptoms (e.g., depressed or elevated mood, decreased engagement in pleasurable activities, increased or decreased energy levels) that develop during or soon after intoxication with or withdrawal from unknown or unspecified psychoactive substances.
• The intensity or duration of the mood symptoms is substantially in excess of mood symptoms that are characteristic of Intoxication due to Unknown or Unspecified Psychoactive Substance or Unknown or Unspecified Psychoactive Substance Withdrawal.
• The symptoms are not better accounted for by another mental disorder such as a Depressive Disorder, a Bipolar Disorder, or Schizophrenia or Other Primary Psychotic Disorder. Evidence supporting a diagnosis of another mental disorder would include mood symptoms preceding the onset of unknown or unspecified psychoactive substance use, the symptoms persisting for a substantial period of time after cessation of unknown or unspecified psychoactive substance use or withdrawal (e.g., 1 month or more), or other evidence of a pre-existing mental disorder with mood symptoms (e.g., a history of prior episodes not associated with unknown or unspecified psychoactive substance use).
• The symptoms are not a manifestation of another medical condition.
• The symptoms cause significant distress or significant impairment in personal, family, social, educational, occupational or other important areas of functioning.

When making a diagnosis of Mood Disorder induced by Unknown or Unspecified Psychoactive Substance, an additional diagnosis indicating the related pattern of unknown or unspecified psychoactive substance use should also be assigned. These include Episode of Harmful Use of Unknown or Unspecified Psychoactive Substances, Harmful Pattern of Use of Unknown or Unspecified Psychoactive Substances, and Unknown or Unspecified Psychoactive Substance Dependence. A diagnosis of Intoxication due to Unknown or Unspecified Psychoactive Substance or Withdrawal due to Unknown or Unspecified Psychoactive Substance may also be assigned if applicable.

Specifiers for unknown or unspecified psychoactive substance-induced mood symptoms:

An additional specifier can be added to denote the presence of either depressive symptoms in the absence of manic symptoms, manic symptoms in the absence of depressive symptoms, or mixed manic and depressive symptoms.

6C4G.700 Mood Disorder induced by Unknown or Unspecified Psychoactive Substance with depressive symptoms

• All diagnostic requirements for Mood Disorder induced by Unknown or Unspecified Psychoactive Substance are met.
• The presentation is characterized by depressive symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.
• Manic symptoms are not present.

6C4G.701 Mood Disorder induced by Unknown or Unspecified Psychoactive Substance with manic symptoms

• All diagnostic requirements for Unknown or Unspecified Psychoactive Substance -Induced Mood Disorder are met.
• The presentation is characterized by manic symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.
• Depressive symptoms are not present.

6C4G.702 Mood Disorder induced by Unknown or Unspecified Psychoactive Substance with mixed depressive and manic symptoms

• All diagnostic requirements for Unknown or Unspecified Psychoactive Substance -Induced Mood Disorder are met.
• The presentation is characterized by both depressive and manic symptoms judged to be the direct consequence of the use of or withdrawal from a specified substance or medication.

6C4G.70Z Mood Disorder induced by Unknown or Unspecified Psychoactive Substance, unspecified

Additional Clinical Features:

• Mood Disorder induced by Unknown or Unspecified Psychoactive Substance may present with patterns of symptoms, depending on the specific substance used, that vary according to the characteristics of the user (e.g., genetics, metabolism, personality factors). Unknown or Unspecified Psychoactive Substances use in higher amounts or over longer periods of time is more likely to be associated with the development of a Mood Disorder induced by Unknown or Unspecified Psychoactive Substance.
• Symptoms of Mood Disorder induced by Unknown or Unspecified Psychoactive Substance usually resolve or improve after sustained cessation of unknown or unspecified psychoactive substance use.
• The duration of Substance Withdrawal for some substances can be protracted. For substances with more protracted withdrawal periods, the onset of symptoms of Substance-Induced Mood Disorder can occur up to several weeks after the cessation of substance use. Substance-Induced Mood Disorder symptoms related to substances with more protracted withdrawal periods may also last for correspondingly longer periods of time.
• In cases in which multiple psychoactive substance are used, it is often challenging to distinguish which substance is the cause of the Substance-Induced Mood Disorder. When the specific etiological substance cannot be determined, a diagnosis of Substance-Induced Mood Disorder Due to Multiple Specified Psychoactive Substances including Medications may assigned. In cases of multiple psychoactive substance use in which more than one specific substance can be identified as a cause of the Substance-Induced Mood Disorder, the corresponding specific Substance-Induced Mood Disorder diagnoses should be given instead.

Boundary with Normality (Threshold):

• Symptoms of Mood Disorder induced by Unknown or Unspecified Psychoactive Substances should be differentiated from known side effects of psychoactive medication that are not significantly impairing or distressing and from transient physiological aftereffects of intoxication (‘hangover effect’). The duration or severity of the symptoms in Mood Disorder induced by Unknown or Unspecified Psychoactive Substances must be in excess of side effects (e.g., transient jitteriness as a side effect of methylphenidate) or ‘hangover effects’ (e.g., transient low mood following alcohol use) of Unknown or Unspecified Psychoactive Substances and result in significant distress or impairment of functioning.

Boundaries with Other Disorders and Conditions (Differential Diagnosis):

• Boundary with Intoxication due to Unknown or Unspecified Psychoactive Substance and Unknown or Unspecified Psychoactive Substance Withdrawal: Mental or behavioural symptoms that occur during Intoxication due to Unknown or Unspecified Psychoactive Substance or Withdrawal due to Unknown or Unspecified Psychoactive Substance should only be used as a basis for diagnosing a Mood Disorder induced by Unknown or Unspecified Psychoactive Substance if the intensity or duration of the symptoms is substantially in excess of those that are characteristic of Intoxication due to Unknown or Unspecified Psychoactive Substance or Withdrawal due to Unknown or Unspecified Psychoactive Substance and the symptoms are sufficiently severe to warrant specific clinical attention.
• Boundary with Episode of Harmful Use of Unknown or Unspecified Psychoactive Substances, Harmful Pattern of Use of Unknown or Unspecified Psychoactive Substances, or Unknown or Unspecified Psychoactive Substance Dependence: The impact of repeated or continuous use of unknown or unspecified psychoactive substances characteristic of Harmful Pattern of Use of Unknown or Unspecified Psychoactive Substances and Unknown or Unspecified Psychoactive Substances Dependence may include Mood Disorder induced by Unknown or Unspecified Psychoactive Substance. Mood Disorder induced by Unknown or Unspecified Psychoactive Substances can also be associated with a single episode of unknown or unspecified psychoactive substance use. In such cases, a Mood Disorder induced by Unknown or Unspecified Psychoactive Substance should be diagnosed together with a primary diagnosis of Episode of Harmful Use of Unknown or Unspecified Psychoactive Substances, Harmful Pattern of Use of Unknown or Unspecified Psychoactive Substances, or Unknown or Unspecified Psychoactive Substance Dependence.
• Boundary with mental disorders not induced by unknown or unspecified psychoactive substances: Mood Disorder induced by Unknown or Unspecified Psychoactive Substances are differentiated from mental disorders with similar features that are not induced by unknown or unspecified psychoactive substances on the basis of their onset, course and clinical features. A diagnosis of Mood Disorder induced by Unknown or Unspecified Psychoactive Substance requires evidence from history, physical or mental examination, or laboratory findings of recent unknown or unspecified psychoactive substance use, intoxication or withdrawal. Most Unknown or Unspecified Psychoactive Substance-Induced Mental Disorders resolve or improve within several weeks of cessation of unknown or unspecified psychoactive substance use. Mental disorders not induced by unknown or unspecified psychoactive substances may precede the onset of unknown or unspecified psychoactive substance use or may continue to be symptomatic during periods of sustained abstinence. The co-occurrence of unknown or unspecified psychoactive substance use or withdrawal and onset of symptoms of mental disorders should not be taken as evidence for a presumptive diagnosis of a Mood Disorder induced by Unknown or Unspecified Psychoactive Substance. Some people use substances to suppress symptoms of mental disorders (e.g., Schizophrenia and Other Primary Psychotic Disorders, Mood Disorders, Anxiety and Fear-Related Disorders, Personality Disorders) and full symptomatic presentations only emerge upon cessation or reduction in substance use. Furthermore, unknown or unspecified psychoactive substance use can exacerbate symptoms or precipitate an episode of a pre-existing mental disorder. Finally, unknown or unspecified psychoactive substance use may be associated with but not aetiologic for new onset of symptoms of a mental disorder. Although a diagnosis of a Mood Disorder induced by Unknown or Unspecified Psychoactive Substance should not be assigned under these circumstances, an additional diagnosis of Episode of Harmful Use of Unknown or Unspecified Psychoactive Substances, Harmful Pattern of Use of Unknown or Unspecified Psychoactive Substances, or Unknown or Unspecified Psychoactive Substance Dependence may still be appropriate.