Delirium due to psychoactive substances including medications

Essential (Required) Features:

• All diagnostic requirements for Delirium are met.
• There is evidence from history, physical examination, or laboratory findings that the neurocognitive disturbance is caused by the direct physiological consequences of use of a substance or medication. This judgment depends on establishing that:
• The substance and the amount and duration of its use or withdrawal from the substance is known to be capable of producing Delirium; and
• The course of the Delirium (e.g., onset, trajectory of symptoms, eventual remission with elimination of the substance from the body) is consistent with causation by the substance.
• The duration or severity of the symptoms is substantially in excess of the characteristic syndrome of Substance Intoxication or Substance Withdrawal due to the specified substance.

Note: Each specific substance that has been identified as contributing to the Delirium should be classified using the appropriate substance-specific category. If one or more of the categories appearing below is diagnosed, a separate diagnosis of 6D70.1 Delirium Due to Psychoactive Substance Including Medications should not be assigned.

• 6C40.5 Alcohol-Induced Delirium (See Table 6.17 for a description of Delirium Associated with Alcohol Withdrawal)
• 6C41.5 Cannabis-Induced Delirium
• 6C42.5 Synthetic Cannabinoid-Induced Delirium
• 6C43.5 Opioid-Induced Delirium
• 6C44.5 Sedative, Hypnotic or Anxiolytic-Induced Delirium (See Table 6.17 for a description of Delirium Associated with Sedative, Hypnotic or Anxiolytic Withdrawal)
• 6C45.5 Cocaine-Induced Delirium
• 6C46.5 Stimulant-Induced Delirium Including Amphetamines, Methamphetamine or Methcathinone
• 6C47.5 Synthetic Cathinone-Induced Delirium
• 6C49.4 Hallucinogen-Induced Delirium
• 6C4B.5 Volatile Inhalant-Induced Delirium
• 6C4C.5 MDMA or Related Drug-Induced Delirium, Including MDA
• 6C4D.4 Dissociative Drug-Induced Delirium Including Ketamine or PCP
• 6C4E.5 Delirium Induced by Other Specified Psychoactive Substance Including Medications
• 6C4F.5 Delirium Induced by Multiple Specified Psychoactive Substances Including Medications
• 6C4G.5 Delirium Induced by Unknown or Unspecified Psychoactive Substance

A diagnosis corresponding to the pattern of use of the relevant psychoactive substance (i.e., Episode of Harmful Psychoactive Substance Use, Harmful Pattern of Psychoactive Substance Use, Substance Dependence) may also be assigned.

If the Delirium is attributed to a substance or medication together with one or more medical conditions, the category Delirium Due to Multiple Etiological Factors should be used instead. This may include medications being used to manage the medical condition.