8C74
Periodic paralyses or disorders of muscle membrane excitability
Paralisias ou transtornos de excitabilidade da membrana muscular periódicos
CategoryDefinition
These are a group of disorders caused by malfunctioning of the ion channels in skeletal muscle membranes causing the cells to depolarize leading to weakness or paralysis. The common triggers include cold, heat, high carbohydrate meals, stress, excitement, physical exertion etc.
Diagnostic Criteria
Signs & symptoms Variable depending on the type. These are caused by mutations in various ion channels including sodium, potassium, or chloride, and thus, are referred as muscle channelopathies.