Drug-induced myopathy
Miopatia induzida por drogas
CategoryDefinition
Drug-induced myopathy is myotoxicity caused by the use of drugs resulting in muscle injury. Two forms of drug-induced myopathy are particularly well known. The first is myopathy due to lipid-lowering agents including fibric acid derivatives, HMG-CoA reductase inhibitors (statins), and niacin (nicotinic acid). Reactions include any combination of muscle aches, cramping, tenderness, or weakness. Indications of toxicity are elevated serum creatinine kinase, myalgia, exercise-induced pain, rhabdomyolysis, and myoglobinuria. The second type is glucocorticoid myopathy that occurs with chronic administration, or as acute quadriplegic myopathy secondary to high-dose IV glucocorticoid use, producing weakness of the proximal muscles and neck flexors. (
Diagnostic Criteria
Signs & symptoms: Variable, resulting in a varying degree of symptomatology, Ranges from mild myalgias with or without mild weakness to chronic myopathy with severe weakness, to massive rhabdomyolysis with acute renal failure.