Non-alcoholic fatty liver disease

Definition

NAFLD is characterised by fatty liver related to insulin resistance in the absence of significant alcohol consumption. It embraces a pathological spectrum from simple steatosis to steatohepatitis. 10-20% of cases have steatohepatitis (non-alcoholic steatohepatitis: NASH), which can progress to cirrhosis and hepatocellular carcinoma.

Exclusions

• Reye syndrome
• Acute fatty liver of pregnancy
• Drug-induced or toxic liver disease
• Chronic hepatitis C
• Alcoholic liver disease
• inherited defects in mitochondrial metabolism

Subcategories (2)