Pauci-immune proliferative glomerulonephritis

Definition

A focal and segmental necrotising glomerulonephritis with no immune deposits (“pauci-immune”). Typical of glomerular involvement in anti-neutrophil cytoplasmic antibody (ANCA) mediated vasculitis – microscopic polyangiitis and Wegener's granulomatosis. Most but not all patients have circulation ANCA when there is active disease.

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